Assay Detail
Functional
CHEMBL834279
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]taurocholate uptake in rat hepatocytes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Hepatic sodium/bile acid cotransporter (CHEMBL4847) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.50 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182472 | — | — | 1 | 8.89 |
| CHEMBL3138128 | — | — | 1 | 8.40 |
| CHEMBL224867 | TAUROCHOLIC ACID | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182472 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3138128 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL224867 | TAUROCHOLIC ACID | IC50 | = | 6000.0 | nM | 5.22 |