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Assay Detail

CHEMBL834286

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of LPA-induced calcium transients in PC-3 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PC-3
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
Durgam GG, Virag T, Walker MD, Tsukahara R, Yasuda S, Liliom K, van Meeteren LA, Moolenaar WH, Wilke N, Siess W, Tigyi G, Miller DD.
J Med Chem (2005) 48 : 4919 -4930
PubMed 16033271 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.77 6.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL190430 1 6.62
CHEMBL190349 1 6.04
CHEMBL187402 1 6.03
CHEMBL363935 1 6.00
CHEMBL187795 THIOPHOSPHORIC ACID DECYL ESTER 1 5.91
CHEMBL188081 1 5.89
CHEMBL363776 1 5.82
CHEMBL363067 1 5.58
CHEMBL191365 THIOPHOSPHORIC ACID DODECYL ESTER 1 5.55
CHEMBL190484 1 5.53
CHEMBL188083 1 5.51
CHEMBL361501 1 5.47
CHEMBL190999 1 5.01
CHEMBL189296 THIOPHOSPHORIC ACID TETRADECYL ESTER 1 -
CHEMBL187459 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL190430 IC50 = 241.0 nM 6.62
CHEMBL190349 IC50 = 916.0 nM 6.04
CHEMBL187402 IC50 = 938.0 nM 6.03
CHEMBL363935 IC50 = 1000.0 nM 6.00
CHEMBL187795 THIOPHOSPHORIC ACID DECYL ESTER IC50 = 1220.0 nM 5.91
CHEMBL188081 IC50 = 1300.0 nM 5.89
CHEMBL363776 IC50 = 1510.0 nM 5.82
CHEMBL363067 IC50 = 2638.0 nM 5.58
CHEMBL191365 THIOPHOSPHORIC ACID DODECYL ESTER IC50 = 2838.0 nM 5.55
CHEMBL190484 IC50 = 2972.0 nM 5.53
CHEMBL188083 IC50 = 3122.0 nM 5.51
CHEMBL361501 IC50 = 3384.0 nM 5.47
CHEMBL190999 IC50 = 9674.0 nM 5.01
CHEMBL189296 THIOPHOSPHORIC ACID TETRADECYL ESTER IC50 - nM -
CHEMBL187459 IC50 - nM -