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Assay Detail

CHEMBL834307

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
TNF-alpha-induced RANTES production in A549 cells using ELISA assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Expert

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 2: Improvement of in vitro activity.
Murata T, Shimada M, Kadono H, Sakakibara S, Yoshino T, Masuda T, Shimazaki M, Shintani T, Fuchikami K, Bacon KB, Ziegelbauer KB, Lowinger TB.
Bioorg Med Chem Lett (2004) 14 : 4013 -4017
PubMed 15225717 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.63 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL363226 1 7.70
CHEMBL360077 1 6.52
CHEMBL181358 1 6.40
CHEMBL184832 1 6.10
CHEMBL185153 1 6.00
CHEMBL182312 1 5.82
CHEMBL183009 1 5.70
CHEMBL182315 1 5.70
CHEMBL360196 1 5.52
CHEMBL179997 1 5.40
CHEMBL183496 1 5.30
CHEMBL184831 1 5.30
CHEMBL365281 1 5.30
CHEMBL362249 1 5.22
CHEMBL173484 1 5.16
CHEMBL173050 1 5.10
CHEMBL182282 1 5.10
CHEMBL182012 1 4.82
CHEMBL361652 1 4.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL363226 IC50 = 20.0 nM 7.70
CHEMBL360077 IC50 = 300.0 nM 6.52
CHEMBL181358 IC50 = 400.0 nM 6.40
CHEMBL184832 IC50 = 800.0 nM 6.10
CHEMBL185153 IC50 = 1000.0 nM 6.00
CHEMBL182312 IC50 = 1500.0 nM 5.82
CHEMBL183009 IC50 = 2000.0 nM 5.70
CHEMBL182315 IC50 = 2000.0 nM 5.70
CHEMBL360196 IC50 = 3000.0 nM 5.52
CHEMBL179997 IC50 = 4000.0 nM 5.40
CHEMBL183496 IC50 = 5000.0 nM 5.30
CHEMBL184831 IC50 = 5000.0 nM 5.30
CHEMBL365281 IC50 = 5000.0 nM 5.30
CHEMBL362249 IC50 = 6000.0 nM 5.22
CHEMBL173484 IC50 = 7000.0 nM 5.16
CHEMBL173050 IC50 = 8000.0 nM 5.10
CHEMBL182282 IC50 = 8000.0 nM 5.10
CHEMBL182012 IC50 = 15000.0 nM 4.82
CHEMBL361652 IC50 = 15000.0 nM 4.82