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Assay Detail

CHEMBL834308

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Functional
TNF-alpha-induced RANTES production in A549 cells using ELISA assay
ChEMBL ↗
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Expert

Target

A549 (CHEMBL392) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents.
Murata T, Shimada M, Sakakibara S, Yoshino T, Masuda T, Shintani T, Sato H, Koriyama Y, Fukushima K, Nunami N, Yamauchi M, Fuchikami K, Komura H, Watanabe A, Ziegelbauer KB, Bacon KB, Lowinger TB.
Bioorg Med Chem Lett (2004) 14 : 4019 -4022
PubMed 15225718 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 6.43 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL368427 — — 1 7.40
CHEMBL361841 — — 1 7.40
CHEMBL369306 — — 1 7.16
CHEMBL360337 — — 1 7.10
CHEMBL183703 — — 1 7.10
CHEMBL182407 — — 1 7.10
CHEMBL181334 — — 1 7.10
CHEMBL181434 — — 1 7.10
CHEMBL182173 — — 1 6.82
CHEMBL181495 — — 1 6.82
CHEMBL361548 — — 1 6.70
CHEMBL182358 — — 1 6.70
CHEMBL183341 — — 1 6.70
CHEMBL182749 — — 1 6.52
CHEMBL361233 — — 1 6.52
CHEMBL360077 — — 1 6.52
CHEMBL360691 — — 1 6.52
CHEMBL363706 — — 1 6.52
CHEMBL185509 — — 1 6.40
CHEMBL181358 — — 1 6.40
CHEMBL183187 — — 1 6.30
CHEMBL180452 — — 1 6.10
CHEMBL425346 — — 1 6.05
CHEMBL425883 — — 1 5.82
CHEMBL181756 — — 1 5.82
CHEMBL361171 — — 1 5.60
CHEMBL182722 — — 1 5.16
CHEMBL433565 — — 1 5.10
CHEMBL182282 — — 1 5.10
CHEMBL173050 — — 1 5.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL368427 — IC50 = 40.0 nM 7.40
CHEMBL361841 — IC50 = 40.0 nM 7.40
CHEMBL369306 — IC50 = 70.0 nM 7.16
CHEMBL360337 — IC50 = 80.0 nM 7.10
CHEMBL183703 — IC50 = 80.0 nM 7.10
CHEMBL182407 — IC50 = 80.0 nM 7.10
CHEMBL181334 — IC50 = 80.0 nM 7.10
CHEMBL181434 — IC50 = 80.0 nM 7.10
CHEMBL182173 — IC50 = 150.0 nM 6.82
CHEMBL181495 — IC50 = 150.0 nM 6.82
CHEMBL361548 — IC50 = 200.0 nM 6.70
CHEMBL182358 — IC50 = 200.0 nM 6.70
CHEMBL183341 — IC50 = 200.0 nM 6.70
CHEMBL182749 — IC50 = 300.0 nM 6.52
CHEMBL361233 — IC50 = 300.0 nM 6.52
CHEMBL360077 — IC50 = 300.0 nM 6.52
CHEMBL360691 — IC50 = 300.0 nM 6.52
CHEMBL363706 — IC50 = 300.0 nM 6.52
CHEMBL185509 — IC50 = 400.0 nM 6.40
CHEMBL181358 — IC50 = 400.0 nM 6.40
CHEMBL183187 — IC50 = 500.0 nM 6.30
CHEMBL180452 — IC50 = 800.0 nM 6.10
CHEMBL425346 — IC50 = 900.0 nM 6.05
CHEMBL425883 — IC50 = 1500.0 nM 5.82
CHEMBL181756 — IC50 = 1500.0 nM 5.82
CHEMBL361171 — IC50 = 2500.0 nM 5.60
CHEMBL182722 — IC50 = 7000.0 nM 5.16
CHEMBL433565 — IC50 = 8000.0 nM 5.10
CHEMBL182282 — IC50 = 8000.0 nM 5.10
CHEMBL173050 — IC50 = 8000.0 nM 5.10
CHEMBL182417 — IC50 > 10000.0 nM -