Assay Detail
Functional
CHEMBL834352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-proliferative activity against HeLa cells in the presence of 150 nM of doxorubicin
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.34 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425904 | — | — | 1 | 6.40 |
| CHEMBL192161 | — | — | 1 | 5.58 |
| CHEMBL195373 | — | — | 1 | 5.30 |
| CHEMBL193117 | — | — | 1 | 5.00 |
| CHEMBL426811 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425904 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL192161 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL195373 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL193117 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL426811 | — | EC50 | = | 37000.0 | nM | 4.43 |