Assay Detail
Functional
CHEMBL834378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against SW620 colorectal carcinoma cell line in MTS assay
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses and biological activities of rebeccamycin analogues with uncommon sugars.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.88 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366225 | — | — | 1 | 5.70 |
| CHEMBL370100 | REBECCAMYCIN | — | 1 | 5.40 |
| CHEMBL326711 | — | — | 1 | 5.30 |
| CHEMBL190559 | — | — | 1 | 4.89 |
| CHEMBL370278 | — | — | 2 | 4.62 |
| CHEMBL365389 | — | — | 1 | 4.50 |
| CHEMBL364025 | — | — | 1 | 4.12 |
| CHEMBL372691 | — | — | 1 | - |
| CHEMBL189103 | — | — | 1 | - |
| CHEMBL192747 | — | — | 1 | - |
| CHEMBL269269 | — | — | 1 | - |
| CHEMBL191848 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366225 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL370100 | REBECCAMYCIN | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL326711 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL190559 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL370278 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL365389 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL370278 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL364025 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL372691 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL189103 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL192747 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL269269 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL191848 | — | IC50 | > | 100000.0 | nM | - |