Assay Detail
Functional
CHEMBL834393
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Concentration required to inhibit growth of human cervical HeLa carcinoma cell line
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.60 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361594 | — | — | 1 | 8.70 |
| CHEMBL181547 | — | — | 1 | 8.21 |
| CHEMBL364360 | — | — | 1 | 8.16 |
| CHEMBL184094 | — | — | 1 | 8.09 |
| CHEMBL359567 | — | — | 1 | 8.05 |
| CHEMBL307794 | — | — | 1 | 8.02 |
| CHEMBL183350 | — | — | 1 | 7.86 |
| CHEMBL360812 | — | — | 1 | 7.79 |
| CHEMBL363752 | — | — | 1 | 7.69 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 2 | 7.59 |
| CHEMBL185306 | — | — | 1 | 7.58 |
| CHEMBL184100 | — | — | 1 | 7.43 |
| CHEMBL188121 | — | — | 1 | 7.09 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.93 |
| CHEMBL364827 | — | — | 1 | 6.69 |
| CHEMBL186541 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361594 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL181547 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL364360 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL184094 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL359567 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL307794 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL183350 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL360812 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL363752 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL185306 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL184100 | — | IC50 | = | 37.3 | nM | 7.43 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 38.8 | nM | 7.41 |
| CHEMBL188121 | — | IC50 | = | 80.9 | nM | 7.09 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 117.2 | nM | 6.93 |
| CHEMBL364827 | — | IC50 | = | 204.1 | nM | 6.69 |
| CHEMBL186541 | — | IC50 | = | 1310.0 | nM | 5.88 |