Assay Detail
Functional
CHEMBL834394
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Concentration required to inhibit growth of human prostate PC-3 carcinoma cell line
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.57 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360812 | — | — | 1 | 8.20 |
| CHEMBL184094 | — | — | 1 | 8.09 |
| CHEMBL185306 | — | — | 1 | 8.09 |
| CHEMBL307794 | — | — | 1 | 8.09 |
| CHEMBL361594 | — | — | 1 | 8.08 |
| CHEMBL181547 | — | — | 1 | 8.05 |
| CHEMBL183350 | — | — | 1 | 8.00 |
| CHEMBL359567 | — | — | 1 | 7.94 |
| CHEMBL364360 | — | — | 1 | 7.87 |
| CHEMBL363752 | — | — | 1 | 7.72 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 2 | 7.45 |
| CHEMBL184100 | — | — | 1 | 7.31 |
| CHEMBL188121 | — | — | 1 | 7.29 |
| CHEMBL186541 | — | — | 1 | 6.77 |
| CHEMBL364827 | — | — | 1 | 6.51 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360812 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL307794 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL184094 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL185306 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL361594 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL181547 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL183350 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL359567 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL364360 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL363752 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 35.6 | nM | 7.45 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 35.3 | nM | 7.45 |
| CHEMBL184100 | — | IC50 | = | 48.7 | nM | 7.31 |
| CHEMBL188121 | — | IC50 | = | 51.2 | nM | 7.29 |
| CHEMBL186541 | — | IC50 | = | 170.5 | nM | 6.77 |
| CHEMBL364827 | — | IC50 | = | 307.6 | nM | 6.51 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1414.4 | nM | 5.85 |