Assay Detail
Functional
CHEMBL834489
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In vivo inhibitory activity against proliferation of normal human peripheral blood T lymphocytes
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.02 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189649 | — | — | 1 | 8.52 |
| CHEMBL185851 | — | — | 1 | 8.22 |
| CHEMBL186498 | — | — | 1 | 7.96 |
| CHEMBL187697 | — | — | 1 | 7.77 |
| CHEMBL186480 | — | — | 1 | 7.72 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 7.30 |
| CHEMBL364623 | — | — | 1 | 7.10 |
| CHEMBL186568 | — | — | 1 | 7.07 |
| CHEMBL365505 | — | — | 1 | 6.97 |
| CHEMBL189776 | — | — | 1 | 6.85 |
| CHEMBL188478 | — | — | 1 | 6.85 |
| CHEMBL361065 | — | — | 1 | 6.81 |
| CHEMBL186177 | — | — | 1 | 6.68 |
| CHEMBL360810 | — | — | 1 | 6.57 |
| CHEMBL186363 | — | — | 1 | 6.46 |
| CHEMBL188675 | — | — | 1 | 6.44 |
| CHEMBL189675 | — | — | 1 | 6.06 |
| CHEMBL189771 | — | — | 1 | 6.05 |
| CHEMBL131577 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189649 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL185851 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL186498 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL187697 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL186480 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL364623 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL186568 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL365505 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL189776 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL188478 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL361065 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL186177 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL360810 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL186363 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL188675 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL189675 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL189771 | — | IC50 | = | 883.0 | nM | 6.05 |
| CHEMBL131577 | — | IC50 | = | 884.0 | nM | 6.05 |