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Assay Detail

CHEMBL834590

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration against growth of A549 lung carcinoma cell
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Expert

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Identification of novel extracellular signal-regulated kinase docking domain inhibitors.
Hancock CN, Macias A, Lee EK, Yu SY, Mackerell AD, Shapiro P.
J Med Chem (2005) 48 : 4586 -4595
PubMed 15999996 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 4.71 4.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL363131 1 4.82
CHEMBL363555 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL363131 IC50 = 15000.0 nM 4.82
CHEMBL363555 IC50 = 25000.0 nM 4.60