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Assay Detail

CHEMBL834644

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration required against growth of HUVEC cancer cell line
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HUVEC
Confidence 1 — Organism
Curated By Intermediate

Target

HUVEC (CHEMBL613979)
Type CELL-LINE
Organism Homo sapiens

Publication

Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization.
Edsall AB, Mohanakrishnan AK, Yang D, Fanwick PE, Hamel E, Hanson AD, Agoston GE, Cushman M.
J Med Chem (2004) 47 : 5126 -5139
PubMed 15456256 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.20 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1627442 1 6.92
CHEMBL1627743 1 6.58
CHEMBL1627461 1 6.28
CHEMBL1628003 1 5.71
CHEMBL1627745 1 5.62
CHEMBL1627631 1 5.51
CHEMBL1628071 1 5.24
CHEMBL1627992 1 5.18
CHEMBL1627431 1 5.11
CHEMBL1627732 1 5.07
CHEMBL1627996 1 4.81
CHEMBL1628001 1 4.68
CHEMBL1627735 1 4.65
CHEMBL1628066 1 4.60
CHEMBL1628187 1 4.54
CHEMBL1627736 1 4.49
CHEMBL1628123 1 4.40
CHEMBL1627744 1 4.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1627442 IC50 = 120.0 nM 6.92
CHEMBL1627743 IC50 = 260.0 nM 6.58
CHEMBL1627461 IC50 = 520.0 nM 6.28
CHEMBL1628003 IC50 = 1940.0 nM 5.71
CHEMBL1627745 IC50 = 2400.0 nM 5.62
CHEMBL1627631 IC50 = 3090.0 nM 5.51
CHEMBL1628071 IC50 = 5700.0 nM 5.24
CHEMBL1627992 IC50 = 6600.0 nM 5.18
CHEMBL1627431 IC50 = 7730.0 nM 5.11
CHEMBL1627732 IC50 = 8510.0 nM 5.07
CHEMBL1627996 IC50 = 15640.0 nM 4.81
CHEMBL1628001 IC50 = 21040.0 nM 4.68
CHEMBL1627735 IC50 = 22500.0 nM 4.65
CHEMBL1628066 IC50 = 25040.0 nM 4.60
CHEMBL1628187 IC50 = 28750.0 nM 4.54
CHEMBL1627736 IC50 = 32270.0 nM 4.49
CHEMBL1628123 IC50 = 40040.0 nM 4.40
CHEMBL1627744 IC50 = 58270.0 nM 4.24