Assay Detail

CHEMBL834675

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibitory concentration against LoVo colon carcinoma cell line

ChEMBL ↗

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Target

LoVo (CHEMBL614721) ↗

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Primary target LoVo

CHEMBL614721

Anchored from Assay target.

Protein identity LoVo

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	LoVo
Confidence	1 — Organism
Curated By	Intermediate

Target

LoVo (CHEMBL614721) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and cytotoxic evaluation of novel spirohydantoin derivatives of the dihydrothieno[2,3-b]naphtho-4,9-dione system.

Gomez-Monterrey I, Santelli G, Campiglia P, Califano D, Falasconi F, Pisano C, Vesci L, Lama T, Grieco P, Novellino E.
J Med Chem (2005) 48 : 1152 -1157
PubMed 15715481 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.06	7.48

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL53463	DOXORUBICIN	4.0	1	7.48
CHEMBL178282	—	—	1	6.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL53463	DOXORUBICIN	IC50	=	33.0	nM	7.48
CHEMBL178282	—	IC50	=	230.0	nM	6.64