Assay Detail
Functional
CHEMBL834682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-Src transformed rat fibroblast proliferation
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Src kinase inhibitory activity of 2-phenyl- and 2-thienyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.03 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 7.00 |
| CHEMBL363575 | — | — | 1 | 6.70 |
| CHEMBL195382 | — | — | 1 | 6.48 |
| CHEMBL370473 | — | — | 1 | 6.46 |
| CHEMBL194503 | — | — | 1 | 6.41 |
| CHEMBL410251 | — | — | 1 | 6.38 |
| CHEMBL194664 | — | — | 1 | 6.37 |
| CHEMBL195419 | — | — | 1 | 6.20 |
| CHEMBL372219 | — | — | 1 | 6.20 |
| CHEMBL192052 | — | — | 1 | 6.16 |
| CHEMBL364955 | — | — | 1 | 6.14 |
| CHEMBL425382 | — | — | 1 | 6.07 |
| CHEMBL190981 | — | — | 1 | 6.05 |
| CHEMBL426990 | — | — | 1 | 5.92 |
| CHEMBL194815 | — | — | 1 | 5.89 |
| CHEMBL194992 | — | — | 1 | 5.85 |
| CHEMBL366029 | — | — | 1 | 5.72 |
| CHEMBL192652 | — | — | 1 | 5.62 |
| CHEMBL373132 | — | — | 1 | 5.52 |
| CHEMBL195523 | — | — | 1 | 5.51 |
| CHEMBL195157 | — | — | 1 | 5.48 |
| CHEMBL425371 | — | — | 1 | 5.40 |
| CHEMBL365398 | — | — | 1 | 5.21 |
| CHEMBL195046 | — | — | 1 | - |
| CHEMBL192679 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL363575 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL195382 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL370473 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL194503 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL410251 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL194664 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL195419 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL372219 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL192052 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL364955 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL425382 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL190981 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL426990 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL194815 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL194992 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL366029 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL192652 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL373132 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL195523 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL195157 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL425371 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL365398 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL195046 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL192679 | — | IC50 | > | 10000.0 | nM | - |