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Assay Detail

CHEMBL834683

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of tubulin polymerization interacting at the colchicine binding site.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Beta tubulin (CHEMBL3186)
Type SINGLE PROTEIN
Organism Leishmania donovani

Publication

Antimitotic activity and reversal of breast cancer resistance protein-mediated drug resistance by stilbenoids from Bletilla striata.
Morita H, Koyama K, Sugimoto Y, Kobayashi J.
Bioorg Med Chem Lett (2005) 15 : 1051 -1054
PubMed 15686910 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 4.92 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL159 VINBLASTINE 4.0 1 6.00
CHEMBL67 COMBRETASTATIN A4 -1.0 1 5.72
CHEMBL182868 1 5.00
CHEMBL182906 1 5.00
CHEMBL181441 1 4.52
CHEMBL181587 1 4.52
CHEMBL369741 CIRRHOPETALANTHRIN 1 4.52
CHEMBL359501 CIRRHOPETALANTHIN 1 4.52
CHEMBL185178 1 4.52
CHEMBL365485 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL159 VINBLASTINE IC50 = 1000.0 nM 6.00
CHEMBL67 COMBRETASTATIN A4 IC50 = 1900.0 nM 5.72
CHEMBL182868 IC50 = 10000.0 nM 5.00
CHEMBL182906 IC50 = 10000.0 nM 5.00
CHEMBL181441 IC50 = 30000.0 nM 4.52
CHEMBL181587 IC50 = 30000.0 nM 4.52
CHEMBL369741 CIRRHOPETALANTHRIN IC50 = 30000.0 nM 4.52
CHEMBL359501 CIRRHOPETALANTHIN IC50 = 30000.0 nM 4.52
CHEMBL185178 IC50 = 30000.0 nM 4.52
CHEMBL365485 IC50 = 300000.0 nM -