Assay Detail
Functional
CHEMBL834693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound tested for the inhibition of HIV-induced cytopathogenicity in MT-2 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.06 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 7.92 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.55 |
| CHEMBL195791 | — | — | 1 | 6.52 |
| CHEMBL364086 | — | — | 1 | 6.25 |
| CHEMBL195666 | — | — | 1 | - |
| CHEMBL192190 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL116 | AMPRENAVIR | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL195791 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL364086 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL195666 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL192190 | — | IC50 | > | 1000.0 | nM | - |