Assay Detail
Functional
CHEMBL834697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit tumor cell growth in KB-V1 cells
71
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 71 | 6.20 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186081 | — | — | 1 | 7.12 |
| CHEMBL182319 | TALTOBULIN | 2.0 | 1 | 7.11 |
| CHEMBL364159 | — | — | 1 | 6.94 |
| CHEMBL189092 | — | — | 1 | 6.94 |
| CHEMBL188372 | — | — | 1 | 6.84 |
| CHEMBL364121 | — | — | 1 | 6.81 |
| CHEMBL186238 | — | — | 1 | 6.75 |
| CHEMBL189817 | — | — | 1 | 6.66 |
| CHEMBL361685 | — | — | 1 | 6.54 |
| CHEMBL181650 | — | — | 1 | 6.52 |
| CHEMBL189648 | — | — | 1 | 6.44 |
| CHEMBL189042 | — | — | 1 | 6.32 |
| CHEMBL188682 | — | — | 1 | 6.29 |
| CHEMBL364107 | — | — | 1 | 6.29 |
| CHEMBL189702 | — | — | 1 | 6.24 |
| CHEMBL454574 | — | — | 1 | 6.06 |
| CHEMBL186143 | — | — | 1 | 5.97 |
| CHEMBL186323 | — | — | 1 | 5.92 |
| CHEMBL363127 | — | — | 1 | 5.88 |
| CHEMBL186875 | — | — | 1 | 5.80 |
| CHEMBL188356 | — | — | 1 | 5.78 |
| CHEMBL362883 | — | — | 1 | 5.75 |
| CHEMBL185704 | — | — | 1 | 5.73 |
| CHEMBL186044 | — | — | 1 | 5.71 |
| CHEMBL362289 | — | — | 1 | 5.63 |
| CHEMBL186983 | — | — | 1 | 5.63 |
| CHEMBL364788 | — | — | 1 | 5.57 |
| CHEMBL186834 | — | — | 1 | 5.28 |
| CHEMBL426261 | — | — | 1 | 5.28 |
| CHEMBL188632 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186081 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL182319 | TALTOBULIN | IC50 | = | 77.4 | nM | 7.11 |
| CHEMBL189092 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL364159 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL188372 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL364121 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL186238 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL189817 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL361685 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL181650 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL189648 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL189042 | — | IC50 | = | 479.0 | nM | 6.32 |
| CHEMBL364107 | — | IC50 | = | 513.0 | nM | 6.29 |
| CHEMBL188682 | — | IC50 | = | 513.0 | nM | 6.29 |
| CHEMBL189702 | — | IC50 | = | 575.0 | nM | 6.24 |
| CHEMBL454574 | — | IC50 | = | 879.0 | nM | 6.06 |
| CHEMBL186143 | — | IC50 | = | 1062.0 | nM | 5.97 |
| CHEMBL186323 | — | IC50 | = | 1189.0 | nM | 5.92 |
| CHEMBL363127 | — | IC50 | = | 1316.0 | nM | 5.88 |
| CHEMBL186875 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL188356 | — | IC50 | = | 1664.0 | nM | 5.78 |
| CHEMBL362883 | — | IC50 | = | 1768.0 | nM | 5.75 |
| CHEMBL185704 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL186044 | — | IC50 | = | 1966.0 | nM | 5.71 |
| CHEMBL186983 | — | IC50 | = | 2347.0 | nM | 5.63 |
| CHEMBL362289 | — | IC50 | = | 2328.0 | nM | 5.63 |
| CHEMBL364788 | — | IC50 | = | 2665.0 | nM | 5.57 |
| CHEMBL186834 | — | IC50 | = | 5248.0 | nM | 5.28 |
| CHEMBL426261 | — | IC50 | = | 5248.0 | nM | 5.28 |
| CHEMBL2096805 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL363114 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL189406 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL2096709 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL184739 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL362764 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL362891 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL188891 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL188632 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL426627 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL363038 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL188724 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL185957 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL189034 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL186187 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL362118 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL189227 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL186997 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL189070 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL185985 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL359983 | — | IC50 | > | 3000.0 | nM | - |