Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL834717

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration of the compound was determined against melanocyte Mel-A cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type B16
Confidence 1 — Organism
Curated By Intermediate

Target

B16 (CHEMBL381)
Type CELL-LINE
Organism Mus musculus

Publication

Retro hydrazino-azapeptoids as peptidomimetics of proteasome inhibitors.
Aubin S, Martin B, Delcros JG, Arlot-Bonnemains Y, Baudy-Floc'h M.
J Med Chem (2005) 48 : 330 -334
PubMed 15634028 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.87 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL179077 1 5.82
CHEMBL180069 1 5.75
CHEMBL178713 1 5.64
CHEMBL178570 1 5.48
CHEMBL361823 1 5.35
CHEMBL369089 1 4.83
CHEMBL367790 1 4.80
CHEMBL178533 1 4.79
CHEMBL433563 1 4.76
CHEMBL179042 1 4.74
CHEMBL178550 1 4.70
CHEMBL178350 1 4.60
CHEMBL180332 1 4.48
CHEMBL179153 1 4.47
CHEMBL264460 1 4.41
CHEMBL178579 1 4.39
CHEMBL175460 1 4.35
CHEMBL179078 1 4.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL179077 IC50 = 1500.0 nM 5.82
CHEMBL180069 IC50 = 1800.0 nM 5.75
CHEMBL178713 IC50 = 2300.0 nM 5.64
CHEMBL178570 IC50 = 3300.0 nM 5.48
CHEMBL361823 IC50 = 4500.0 nM 5.35
CHEMBL369089 IC50 = 14800.0 nM 4.83
CHEMBL367790 IC50 = 15800.0 nM 4.80
CHEMBL178533 IC50 = 16300.0 nM 4.79
CHEMBL433563 IC50 = 17300.0 nM 4.76
CHEMBL179042 IC50 = 18400.0 nM 4.74
CHEMBL178550 IC50 = 19900.0 nM 4.70
CHEMBL178350 IC50 = 25100.0 nM 4.60
CHEMBL180332 IC50 = 33300.0 nM 4.48
CHEMBL179153 IC50 = 33700.0 nM 4.47
CHEMBL264460 IC50 = 39300.0 nM 4.41
CHEMBL178579 IC50 = 40300.0 nM 4.39
CHEMBL175460 IC50 = 45100.0 nM 4.35
CHEMBL179078 IC50 = 60900.0 nM 4.21