Assay Detail
Functional
CHEMBL834744
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Inhibition concentration against ADP-induced platelet aggregation using human platelet rich plasma
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Cell Type | Cell line |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.97 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494 | ILOPROST | 4.0 | 1 | 8.60 |
| CHEMBL195456 | — | — | 1 | 8.24 |
| CHEMBL197319 | — | — | 1 | 7.28 |
| CHEMBL196935 | — | — | 1 | 7.04 |
| CHEMBL268477 | AP-227 | — | 1 | 6.82 |
| CHEMBL196194 | — | — | 1 | 6.77 |
| CHEMBL426829 | — | — | 1 | 6.57 |
| CHEMBL425916 | — | — | 1 | 5.89 |
| CHEMBL371399 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494 | ILOPROST | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL195456 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL197319 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL196935 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL268477 | AP-227 | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL196194 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL426829 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL425916 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL371399 | — | IC50 | = | 3200.0 | nM | 5.50 |