Assay Detail
Functional
CHEMBL834748
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of corticotropin releasing factor stimulated cAMP production in rat pituitary assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Pituitary gland |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Corticotropin releasing factor receptor (CHEMBL2111360) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Rational design, synthesis, and structure-activity relationships of aryltriazoles as novel corticotropin-releasing factor-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.93 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2094063 | — | — | 1 | 7.31 |
| CHEMBL3085414 | — | — | 1 | 7.25 |
| CHEMBL110609 | — | — | 1 | 7.05 |
| CHEMBL3085416 | — | — | 1 | 7.04 |
| CHEMBL2093962 | — | — | 1 | 7.04 |
| CHEMBL2094043 | — | — | 1 | 6.92 |
| CHEMBL2094044 | — | — | 1 | 6.92 |
| CHEMBL3085417 | — | — | 1 | 6.62 |
| CHEMBL3085418 | — | — | 1 | 6.62 |
| CHEMBL3085415 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2094063 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3085414 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL110609 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3085416 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL2093962 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL2094043 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2094044 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3085417 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3085418 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3085415 | — | IC50 | = | 270.0 | nM | 6.57 |