Assay Detail
Functional
CHEMBL834754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against SKBr3 cell line
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 4.68 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365159 | — | — | 1 | 6.70 |
| CHEMBL191635 | — | — | 1 | 6.24 |
| CHEMBL192145 | — | — | 1 | 5.96 |
| CHEMBL193282 | — | — | 1 | 5.75 |
| CHEMBL112953 | — | — | 1 | 5.75 |
| CHEMBL273986 | — | — | 1 | 5.72 |
| CHEMBL192062 | — | — | 1 | 5.50 |
| CHEMBL191786 | — | — | 1 | 5.48 |
| CHEMBL192647 | — | — | 1 | 5.03 |
| CHEMBL370247 | — | — | 1 | 5.00 |
| CHEMBL191268 | — | — | 1 | 4.83 |
| CHEMBL363196 | — | — | 1 | 4.79 |
| CHEMBL349231 | — | — | 1 | 4.78 |
| CHEMBL193259 | — | — | 1 | 4.74 |
| CHEMBL191920 | — | — | 1 | 4.68 |
| CHEMBL364456 | — | — | 1 | 4.67 |
| CHEMBL189537 | — | — | 1 | 4.60 |
| CHEMBL190518 | — | — | 1 | 4.57 |
| CHEMBL426086 | — | — | 1 | 4.52 |
| CHEMBL424824 | — | — | 1 | 4.50 |
| CHEMBL195096 | — | — | 1 | 4.46 |
| CHEMBL194716 | — | — | 1 | 4.44 |
| CHEMBL191241 | — | — | 1 | 4.44 |
| CHEMBL192937 | — | — | 1 | 4.43 |
| CHEMBL195869 | — | — | 1 | 4.42 |
| CHEMBL161992 | — | — | 1 | 4.39 |
| CHEMBL439852 | — | — | 1 | 4.38 |
| CHEMBL427169 | — | — | 1 | 4.38 |
| CHEMBL370286 | — | — | 1 | 4.38 |
| CHEMBL191601 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365159 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL191635 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL192145 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL193282 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL112953 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL273986 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL192062 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL191786 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL192647 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL370247 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL191268 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL363196 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL349231 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL193259 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL191920 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL364456 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL189537 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL190518 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL426086 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL424824 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL195096 | — | IC50 | = | 34400.0 | nM | 4.46 |
| CHEMBL194716 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL191241 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL192937 | — | IC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL195869 | — | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL161992 | — | IC50 | = | 40500.0 | nM | 4.39 |
| CHEMBL427169 | — | IC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL370286 | — | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL439852 | — | IC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL191601 | — | IC50 | = | 42300.0 | nM | 4.37 |
| CHEMBL192761 | — | IC50 | = | 43900.0 | nM | 4.36 |
| CHEMBL364450 | — | IC50 | = | 44100.0 | nM | 4.36 |
| CHEMBL192480 | — | IC50 | = | 48400.0 | nM | 4.32 |
| CHEMBL192649 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL362972 | — | IC50 | = | 57600.0 | nM | 4.24 |
| CHEMBL372013 | — | IC50 | = | 57200.0 | nM | 4.24 |
| CHEMBL193672 | — | IC50 | = | 63400.0 | nM | 4.20 |
| CHEMBL191641 | — | IC50 | = | 65400.0 | nM | 4.18 |
| CHEMBL191668 | — | IC50 | = | 66700.0 | nM | 4.18 |
| CHEMBL370092 | — | IC50 | = | 66200.0 | nM | 4.18 |
| CHEMBL193310 | — | IC50 | = | 68400.0 | nM | 4.17 |
| CHEMBL193313 | — | IC50 | = | 68800.0 | nM | 4.16 |
| CHEMBL352683 | — | IC50 | = | 71100.0 | nM | 4.15 |
| CHEMBL371372 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL190654 | — | IC50 | = | 85800.0 | nM | 4.07 |
| CHEMBL364272 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL190439 | — | IC50 | = | 122000.0 | nM | - |
| CHEMBL193892 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL190438 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL415775 | — | IC50 | = | 130000.0 | nM | - |