Assay Detail
Functional
CHEMBL834765
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In vitro Inhibition against PGE-2 using IL-1-beta-stimulated A549 epithelial lung carcinoma cells in the presence of 2% FBS
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.44 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180650 | — | — | 1 | 6.57 |
| CHEMBL182032 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180650 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL182032 | — | IC50 | = | 490.0 | nM | 6.31 |