Assay Detail
Functional
CHEMBL834791
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Human umbilical vein endothelial cells stimulated by VEGF was determined
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Cell line |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.19 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178607 | — | — | 1 | 9.00 |
| CHEMBL369322 | — | — | 1 | 9.00 |
| CHEMBL180978 | — | — | 1 | 8.52 |
| CHEMBL360769 | — | — | 1 | 8.40 |
| CHEMBL360118 | — | — | 1 | 8.30 |
| CHEMBL359652 | — | — | 1 | 8.22 |
| CHEMBL179517 | — | — | 1 | 8.10 |
| CHEMBL178583 | — | — | 1 | 8.00 |
| CHEMBL180603 | — | — | 1 | 7.70 |
| CHEMBL360450 | — | — | 1 | 7.46 |
| CHEMBL178596 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178607 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL369322 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL180978 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL360769 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL360118 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL359652 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL179517 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL178583 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL180603 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL360450 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL178596 | — | IC50 | = | 40.0 | nM | 7.40 |