Assay Detail
Functional
CHEMBL834795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxic concentration against human A549 lung cancer cell line determined by sulforhodamine B dye-staining method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, antitumor evaluation and DNA photocleaving activity of novel methylthiazonaphthalimides with aminoalkyl side chains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.65 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371556 | — | — | 1 | 7.68 |
| CHEMBL365563 | — | — | 1 | 7.08 |
| CHEMBL191590 | — | — | 1 | 6.80 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.96 |
| CHEMBL193026 | — | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371556 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL365563 | — | IC50 | = | 82.8 | nM | 7.08 |
| CHEMBL191590 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL193026 | — | IC50 | = | 1804.0 | nM | 5.74 |