Assay Detail

CHEMBL834798

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

In vitro inhibition against chloroquine-resistant Plasmodium falciparum V1/S; Range 0.1-0.4 uM

ChEMBL ↗

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Target

Plasmodium falciparum (CHEMBL364) ↗

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Primary target Plasmodium falciparum

CHEMBL364

Anchored from Assay target.

Protein identity Plasmodium falciparum

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Plasmodium falciparum
Confidence	1 — Organism
Curated By	Intermediate

Target

Plasmodium falciparum (CHEMBL364) ↗

Type	ORGANISM
Organism	Plasmodium falciparum

Publication

Antimalarial benzo[c]phenanthridines.

Nyangulu JM, Hargreaves SL, Sharples SL, Mackay SP, Waigh RD, Duval O, Mberu EK, Watkins WM.
Bioorg Med Chem Lett (2005) 15 : 2007 -2010
PubMed 15808457 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.40	6.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL8443	NITIDINE CHLORIDE	—	1	6.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL8443	NITIDINE CHLORIDE	IC50	=	400.0	nM	6.40