Assay Detail
Functional
CHEMBL834809
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Inhibitory concentration was measured by the incorporation of [14C]thymidine in (human breast carcinoma) MDA-MB-435
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.09 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370295 | — | — | 1 | 6.66 |
| CHEMBL372712 | — | — | 1 | 6.38 |
| CHEMBL189978 | — | — | 1 | 6.24 |
| CHEMBL192749 | — | — | 1 | 6.24 |
| CHEMBL191138 | — | — | 1 | 5.85 |
| CHEMBL193167 | — | — | 1 | 5.71 |
| CHEMBL189215 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370295 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL372712 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL189978 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL192749 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL191138 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL193167 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL189215 | — | IC50 | = | 2770.0 | nM | 5.56 |