Assay Detail
Functional
CHEMBL834816
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human FGF receptor expressing ovarian carcinoma cell proliferation
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Fibroblast growth factor receptor (CHEMBL2095217) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.92 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425363 | — | — | 1 | 7.38 |
| CHEMBL278472 | — | — | 1 | 7.25 |
| CHEMBL189691 | — | — | 1 | 6.77 |
| CHEMBL192856 | — | — | 1 | 6.70 |
| CHEMBL190161 | — | — | 1 | 6.70 |
| CHEMBL189995 | — | — | 1 | 6.48 |
| CHEMBL191070 | — | — | 1 | 6.47 |
| CHEMBL187396 | — | — | 1 | 6.46 |
| CHEMBL191023 | — | — | 1 | 6.25 |
| CHEMBL365727 | — | — | 1 | 6.20 |
| CHEMBL363551 | — | — | 1 | 5.77 |
| CHEMBL190389 | — | — | 1 | 5.35 |
| CHEMBL189059 | — | — | 1 | 5.34 |
| CHEMBL188087 | — | — | 1 | 5.32 |
| CHEMBL191265 | — | — | 1 | 5.19 |
| CHEMBL365140 | — | — | 1 | 5.17 |
| CHEMBL189851 | — | — | 1 | 5.17 |
| CHEMBL188978 | — | — | 1 | 4.92 |
| CHEMBL189584 | PD-173074 | — | 1 | 4.89 |
| CHEMBL190783 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425363 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL278472 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL189691 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL192856 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL190161 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL189995 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL191070 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL187396 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL191023 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL365727 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL363551 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL190389 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL189059 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL188087 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL191265 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL365140 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL189851 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL188978 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL189584 | PD-173074 | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL190783 | — | IC50 | = | 25000.0 | nM | 4.60 |