Assay Detail
Functional
CHEMBL834874
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration for intracellular cAMP accumulation in human melanocortin 1 receptor expressing HEK 293 cells; (N = 4)
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanocyte-stimulating hormone receptor (CHEMBL3795) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 8.08 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 9.15 |
| CHEMBL414778 | — | — | 1 | 8.82 |
| CHEMBL443071 | — | — | 1 | 8.82 |
| CHEMBL2371712 | — | — | 1 | 8.70 |
| CHEMBL438920 | — | — | 1 | 8.70 |
| CHEMBL413439 | — | — | 1 | 8.52 |
| CHEMBL2096759 | — | — | 1 | 8.10 |
| CHEMBL2310901 | — | — | 1 | 7.26 |
| CHEMBL437050 | — | — | 2 | 7.16 |
| CHEMBL411359 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214332 | INTERMEDINE | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL414778 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL443071 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2371712 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL438920 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL413439 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2096759 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2310901 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL437050 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL411359 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL437050 | — | EC50 | = | 300.0 | nM | 6.52 |