Assay Detail
Functional
CHEMBL834888
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Inhibition constant against human recombinant carbonic anhydrase IX catalytic domain
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.36 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189065 | — | — | 1 | 8.14 |
| CHEMBL189729 | — | — | 1 | 8.12 |
| CHEMBL192997 | — | — | 1 | 8.03 |
| CHEMBL193191 | — | — | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL373325 | — | — | 1 | 7.38 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL189113 | — | — | 1 | 7.28 |
| CHEMBL190448 | — | — | 1 | 7.10 |
| CHEMBL190392 | — | — | 1 | 7.10 |
| CHEMBL190447 | — | — | 1 | 7.09 |
| CHEMBL191799 | — | — | 1 | 7.09 |
| CHEMBL190622 | — | — | 1 | 7.09 |
| CHEMBL193199 | — | — | 1 | 7.08 |
| CHEMBL364903 | — | — | 1 | 7.08 |
| CHEMBL190314 | — | — | 1 | 7.05 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189065 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL189729 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL192997 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL193191 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL373325 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL189113 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL190448 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL190392 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL190447 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL191799 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL190622 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL193199 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL364903 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL190314 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 294.0 | nM | 6.53 |