Assay Detail
Functional
CHEMBL834931
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dissociation constant for binding to inactivated state of rat brain NaIIa (rNav1.2) -B2 cell line stably expressed in HEK293 Cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Intermediate |
Publication
Phenoxyphenyl pyridines as novel state-dependent, high-potency sodium channel inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.13 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188987 | — | — | 1 | 7.70 |
| CHEMBL360599 | — | — | 1 | 7.05 |
| CHEMBL188570 | — | — | 1 | 6.92 |
| CHEMBL189873 | — | — | 1 | 6.82 |
| CHEMBL186147 | — | — | 1 | 6.77 |
| CHEMBL187228 | — | — | 1 | 6.60 |
| CHEMBL287833 | — | — | 1 | 6.46 |
| CHEMBL363448 | — | — | 1 | 6.44 |
| CHEMBL186185 | — | — | 1 | 6.23 |
| CHEMBL189086 | — | — | 1 | 5.58 |
| CHEMBL189555 | — | — | 1 | 5.43 |
| CHEMBL365720 | — | — | 1 | 4.87 |
| CHEMBL741 | LAMOTRIGINE | 4.0 | 1 | 4.54 |
| CHEMBL108 | CARBAMAZEPINE | 4.0 | 1 | 4.34 |
| CHEMBL366331 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188987 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL360599 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL188570 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL189873 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL186147 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL187228 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL287833 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL363448 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL186185 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL189086 | — | Ki | = | 2640.0 | nM | 5.58 |
| CHEMBL189555 | — | Ki | = | 3750.0 | nM | 5.43 |
| CHEMBL365720 | — | Ki | = | 13400.0 | nM | 4.87 |
| CHEMBL741 | LAMOTRIGINE | Ki | = | 29200.0 | nM | 4.54 |
| CHEMBL108 | CARBAMAZEPINE | Ki | = | 46100.0 | nM | 4.34 |
| CHEMBL366331 | — | Ki | = | 386000.0 | nM | - |