Assay Detail
Binding
CHEMBL834977
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Inhibitory constant against human placental atomatase at pH 7.0 and 37 degree C
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and characterization of azole isoflavone inhibitors of aromatase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.77 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363493 | — | — | 1 | 6.60 |
| CHEMBL192306 | — | — | 1 | 6.17 |
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 5.85 |
| CHEMBL189472 | — | — | 1 | 5.74 |
| CHEMBL189274 | — | — | 1 | 5.36 |
| CHEMBL131921 | BIOCHANIN | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363493 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL192306 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL488 | AMINOGLUTETHIMIDE | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL189472 | — | Ki | = | 1820.0 | nM | 5.74 |
| CHEMBL189274 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL131921 | BIOCHANIN | Ki | = | 12000.0 | nM | 4.92 |