Assay Detail
Functional
CHEMBL835014
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Inhibition of electrically evoked contraction of guinea pig ileum
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.74 | 8.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414782 | — | — | 1 | 8.98 |
| CHEMBL410653 | — | — | 1 | 8.95 |
| CHEMBL264846 | — | — | 1 | 8.73 |
| CHEMBL396460 | NOCICEPTIN | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414782 | — | EC50 | = | 1.047 | nM | 8.98 |
| CHEMBL410653 | — | EC50 | = | 1.122 | nM | 8.95 |
| CHEMBL264846 | — | EC50 | = | 1.862 | nM | 8.73 |
| CHEMBL396460 | NOCICEPTIN | EC50 | = | 5.248 | nM | 8.28 |