Assay Detail
Functional
CHEMBL835018
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Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 9.34 | 10.18 |
| Log EC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264846 | — | — | 1 | 10.18 |
| CHEMBL414782 | — | — | 1 | 10.17 |
| CHEMBL410653 | — | — | 1 | 10.00 |
| CHEMBL396460 | NOCICEPTIN | — | 1 | 9.94 |
| CHEMBL262544 | — | — | 1 | 9.62 |
| CHEMBL442297 | — | — | 1 | 9.52 |
| CHEMBL263588 | — | — | 1 | 9.32 |
| CHEMBL414767 | — | — | 1 | 9.12 |
| CHEMBL411649 | — | — | 1 | 8.31 |
| CHEMBL413944 | — | — | 1 | 7.26 |
| CHEMBL411621 | — | — | 1 | - |
| CHEMBL410145 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264846 | — | EC50 | = | 0.06607 | nM | 10.18 |
| CHEMBL414782 | — | EC50 | = | 0.06761 | nM | 10.17 |
| CHEMBL410653 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL396460 | NOCICEPTIN | EC50 | = | 0.1148 | nM | 9.94 |
| CHEMBL262544 | — | EC50 | = | 0.2399 | nM | 9.62 |
| CHEMBL442297 | — | EC50 | = | 0.302 | nM | 9.52 |
| CHEMBL263588 | — | EC50 | = | 0.4786 | nM | 9.32 |
| CHEMBL414767 | — | EC50 | = | 0.7586 | nM | 9.12 |
| CHEMBL411649 | — | EC50 | = | 4.898 | nM | 8.31 |
| CHEMBL413944 | — | EC50 | = | 54.95 | nM | 7.26 |
| CHEMBL411621 | — | Log EC50 | - | — | - | |
| CHEMBL410145 | — | Log EC50 | - | — | - |