Assay Detail
Functional
CHEMBL835221
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In vitro antiplasmodial activity for Plasmodium falciparum
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.50 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191791 | — | — | 1 | 7.52 |
| CHEMBL450632 | — | — | 1 | 7.43 |
| CHEMBL1162901 | — | — | 1 | 7.35 |
| CHEMBL192343 | — | — | 1 | 7.31 |
| CHEMBL189923 | — | — | 1 | 7.20 |
| CHEMBL366168 | — | — | 1 | 7.16 |
| CHEMBL193834 | — | — | 1 | 7.06 |
| CHEMBL363821 | — | — | 1 | 6.83 |
| CHEMBL365520 | — | — | 1 | 6.78 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 6.61 |
| CHEMBL364685 | — | — | 1 | 6.58 |
| CHEMBL191789 | — | — | 1 | 6.58 |
| CHEMBL370710 | — | — | 1 | 6.45 |
| CHEMBL373109 | — | — | 1 | 6.38 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 6.36 |
| CHEMBL553878 | — | — | 1 | 6.36 |
| CHEMBL371382 | — | — | 1 | 6.35 |
| CHEMBL610246 | — | — | 1 | 6.19 |
| CHEMBL191734 | — | — | 1 | 6.02 |
| CHEMBL92023 | — | — | 1 | 5.92 |
| CHEMBL189152 | — | — | 1 | 5.33 |
| CHEMBL610245 | — | — | 1 | 5.16 |
| CHEMBL189840 | — | — | 1 | 4.57 |
| CHEMBL190189 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191791 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL450632 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1162901 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL192343 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL189923 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL366168 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL193834 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL363821 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL365520 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL364685 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL191789 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL370710 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL373109 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL553878 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL371382 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL610246 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL191734 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL92023 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL189152 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL610245 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL189840 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL190189 | — | IC50 | > | 1000.0 | nM | - |