Assay Detail
Functional
CHEMBL835228
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Concentration causing inhibition of CCRF-CEM human leukemic lymphoblasts growth in 72 hr culture
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.42 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187595 | — | — | 1 | 5.55 |
| CHEMBL189952 | — | — | 1 | 5.43 |
| CHEMBL190486 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187595 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL189952 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL190486 | — | IC50 | = | 5300.0 | nM | 5.28 |