Assay Detail
Functional
CHEMBL835234
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against cell proliferation in human PC-3 (prostate adenocarcinoma) tumor cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.89 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187395 | — | — | 1 | 7.43 |
| CHEMBL363130 | — | — | 1 | 6.96 |
| CHEMBL191003 | JNJ-7706621 | — | 1 | 6.92 |
| CHEMBL363607 | — | — | 1 | 6.80 |
| CHEMBL190643 | — | — | 1 | 6.80 |
| CHEMBL361900 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187395 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL363130 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL191003 | JNJ-7706621 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL363607 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL190643 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL361900 | — | IC50 | = | 370.0 | nM | 6.43 |