Assay Detail
Functional
CHEMBL835235
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In vitro inhibitory concentration against cell proliferation in human HeLa (cervical adenocarcinoma) tumor cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.58 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261720 | — | — | 1 | 7.46 |
| CHEMBL187395 | — | — | 1 | 7.14 |
| CHEMBL363130 | — | — | 1 | 7.04 |
| CHEMBL364927 | — | — | 1 | 6.89 |
| CHEMBL190453 | — | — | 1 | 6.85 |
| CHEMBL425720 | — | — | 1 | 6.66 |
| CHEMBL361900 | — | — | 1 | 6.58 |
| CHEMBL191003 | JNJ-7706621 | — | 1 | 6.55 |
| CHEMBL363607 | — | — | 1 | 6.43 |
| CHEMBL190643 | — | — | 1 | 6.26 |
| CHEMBL190171 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261720 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL187395 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL363130 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL364927 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL190453 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL425720 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL361900 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL191003 | JNJ-7706621 | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL363607 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL190643 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL190171 | — | IC50 | = | 28500.0 | nM | 4.54 |