Assay Detail
Functional
CHEMBL835243
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Inhibition of ER-MDA-MB 231 breast cancer cell proliferation over 200 hr
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Cancer cell lines |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of stilbene-based pure estrogen antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.73 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 9.68 |
| CHEMBL185209 | — | — | 1 | 9.66 |
| CHEMBL184285 | — | — | 1 | 9.12 |
| CHEMBL184074 | — | — | 1 | 8.85 |
| CHEMBL426065 | — | — | 1 | 8.29 |
| CHEMBL365089 | — | — | 1 | 8.21 |
| CHEMBL183345 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL185209 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL184285 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL184074 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL426065 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL365089 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL183345 | — | IC50 | = | 49.0 | nM | 7.31 |