Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL835264

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Ability of compound to inhibit dopamine uptake of receptor was determined
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Sodium-dependent dopamine transporter (CHEMBL238)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The role of QSAR in dopamine interactions.
Hansch C, Verma RP, Kurup A, Mekapati SB.
Bioorg Med Chem Lett (2005) 15 : 2149 -2157
PubMed 15808487 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 7.50 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3085020 1 8.30
CHEMBL115253 1 8.19
CHEMBL324518 1 8.09
CHEMBL317757 DIFLUOROBENZTROPINE 1 7.86
CHEMBL112528 1 7.85
CHEMBL327055 1 7.73
CHEMBL325826 1 7.65
CHEMBL3084884 1 7.63
CHEMBL3085021 1 7.59
CHEMBL2308105 1 7.41
CHEMBL326706 1 7.31
CHEMBL111928 1 6.64
CHEMBL370805 COCAINE 4.0 1 6.63
CHEMBL115710 1 6.18

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3085020 Ki = 5.012 nM 8.30
CHEMBL115253 Ki = 6.457 nM 8.19
CHEMBL324518 Ki = 8.128 nM 8.09
CHEMBL317757 DIFLUOROBENZTROPINE Ki = 13.8 nM 7.86
CHEMBL112528 Ki = 14.13 nM 7.85
CHEMBL327055 Ki = 18.62 nM 7.73
CHEMBL325826 Ki = 22.39 nM 7.65
CHEMBL3084884 Ki = 23.44 nM 7.63
CHEMBL3085021 Ki = 25.7 nM 7.59
CHEMBL2308105 Ki = 38.9 nM 7.41
CHEMBL326706 Ki = 48.98 nM 7.31
CHEMBL111928 Ki = 229.09 nM 6.64
CHEMBL370805 COCAINE Ki = 234.42 nM 6.63
CHEMBL115710 Ki = 660.69 nM 6.18