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Assay Detail

CHEMBL835382

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Binding
Binding affinity towards dopamine receptor D2 was determined
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

The role of QSAR in dopamine interactions.
Hansch C, Verma RP, Kurup A, Mekapati SB.
Bioorg Med Chem Lett (2005) 15 : 2149 -2157
PubMed 15808487 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 7.93 9.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL54 HALOPERIDOL 4.0 2 9.05
CHEMBL148794 1 8.96
CHEMBL193577 1 8.10
CHEMBL147830 1 7.81
CHEMBL149721 1 7.81
CHEMBL148627 1 7.81
CHEMBL358190 1 7.64
CHEMBL195231 1 7.58
CHEMBL150161 1 7.48
CHEMBL149877 1 7.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL54 HALOPERIDOL Ki = 0.8913 nM 9.05
CHEMBL148794 Ki = 1.096 nM 8.96
CHEMBL193577 Ki = 7.943 nM 8.10
CHEMBL147830 Ki = 15.49 nM 7.81
CHEMBL149721 Ki = 15.49 nM 7.81
CHEMBL148627 Ki = 15.49 nM 7.81
CHEMBL358190 Ki = 22.91 nM 7.64
CHEMBL54 HALOPERIDOL Ki = 23.99 nM 7.62
CHEMBL195231 Ki = 26.3 nM 7.58
CHEMBL150161 Ki = 33.11 nM 7.48
CHEMBL149877 Ki = 43.65 nM 7.36