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Assay Detail

CHEMBL835393

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Binding
Binding affinity towards human dopamine receptor D4 expressed in CHO cells was determined by using [3H]thymidine as radioligand
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

D(4) dopamine receptor (CHEMBL219)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The role of QSAR in dopamine interactions.
Hansch C, Verma RP, Kurup A, Mekapati SB.
Bioorg Med Chem Lett (2005) 15 : 2149 -2157
PubMed 15808487 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 7.90 8.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL300956 1 8.92
CHEMBL51023 1 8.47
CHEMBL49231 1 8.46
CHEMBL49876 1 8.41
CHEMBL49502 1 8.28
CHEMBL296953 1 8.08
CHEMBL296506 1 7.89
CHEMBL48819 1 7.82
CHEMBL298166 1 7.80
CHEMBL45244 PD-168,077 1 7.77
CHEMBL423659 1 7.62
CHEMBL48807 1 7.51
CHEMBL298763 1 6.97
CHEMBL51536 1 6.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL300956 Ki = 1.202 nM 8.92
CHEMBL51023 Ki = 3.388 nM 8.47
CHEMBL49231 Ki = 3.467 nM 8.46
CHEMBL49876 Ki = 3.89 nM 8.41
CHEMBL49502 Ki = 5.248 nM 8.28
CHEMBL296953 Ki = 8.318 nM 8.08
CHEMBL296506 Ki = 12.88 nM 7.89
CHEMBL48819 Ki = 15.14 nM 7.82
CHEMBL298166 Ki = 15.85 nM 7.80
CHEMBL45244 PD-168,077 Ki = 16.98 nM 7.77
CHEMBL423659 Ki = 23.99 nM 7.62
CHEMBL48807 Ki = 30.9 nM 7.51
CHEMBL298763 Ki = 107.15 nM 6.97
CHEMBL51536 Ki = 218.78 nM 6.66