Assay Detail
Functional
CHEMBL835774
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Inhibition of NYH Cell line
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NSCLC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
EB1627: a soluble prodrug of the potent anticancer cyanoguanidine CHS828.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.91 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362089 | — | — | 1 | 9.40 |
| CHEMBL17289 | CHS-828 | 1.0 | 1 | 9.30 |
| CHEMBL190041 | — | — | 1 | 9.30 |
| CHEMBL189208 | — | — | 1 | 9.20 |
| CHEMBL190412 | TEGLARINAD CHLORIDE | 2.0 | 1 | 9.10 |
| CHEMBL189478 | — | — | 1 | 8.30 |
| CHEMBL363430 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362089 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL17289 | CHS-828 | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL190041 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL189208 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL190412 | TEGLARINAD CHLORIDE | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL189478 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL363430 | — | IC50 | = | 15.85 | nM | 7.80 |