Assay Detail
Functional
CHEMBL835873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity as inhibition of 1 nM 17-beta-estradiol stimulated alkaline phosphatase induction in Ishikawa endometrial cells
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Ishikawa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Benzothiophene and naphthalene derived constrained SERMs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.75 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360872 | — | — | 3 | 7.55 |
| CHEMBL184958 | — | — | 1 | 7.35 |
| CHEMBL184976 | — | — | 1 | 7.30 |
| CHEMBL185412 | — | — | 1 | 7.28 |
| CHEMBL184423 | — | — | 1 | 6.89 |
| CHEMBL2137046 | — | — | 1 | 6.29 |
| CHEMBL360005 | — | — | 1 | 6.24 |
| CHEMBL185284 | — | — | 1 | 6.17 |
| CHEMBL182342 | — | — | 1 | 6.16 |
| CHEMBL185064 | — | — | 1 | 6.15 |
| CHEMBL183685 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360872 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL360872 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL184958 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL184976 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL185412 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL184423 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL360872 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2137046 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL360005 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL185284 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL182342 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL185064 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL183685 | — | IC50 | = | 820.0 | nM | 6.09 |