Assay Detail

CHEMBL836355

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Functional

Compound was tested for the cytotoxicity against KB-3-1 cell line; value ranges from 0.6-2 nM

ChEMBL ↗

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Target

KB 3-1 (CHEMBL614590) ↗

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Primary target KB 3-1

CHEMBL614590

Anchored from Assay target.

Protein identity KB 3-1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	KB 3-1
Confidence	1 — Organism
Curated By	Intermediate

Target

KB 3-1 (CHEMBL614590) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents.

Niu C, Smith D, Zask A, Loganzo F, Discafani C, Beyer C, Greenberger L, Ayral-Kaloustian S.
Bioorg Med Chem Lett (2004) 14 : 4329 -4332
PubMed 15261296 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.70	8.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL182319	TALTOBULIN	2.0	1	8.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL182319	TALTOBULIN	IC50	=	2.0	nM	8.70