Assay Detail
Functional
CHEMBL837263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The concentration required for inhibiting the growth of the murine P815 mastocytoma cells by 50%
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P815 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A novel class of in vivo active anticancer agents: achiral seco-amino- and seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) analogues of the duocarmycins and CC-1065.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.67 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191295 | — | — | 1 | 8.07 |
| CHEMBL195315 | — | — | 1 | 7.60 |
| CHEMBL192069 | CENTANAMYCIN | — | 1 | 7.17 |
| CHEMBL183826 | — | — | 1 | 5.27 |
| CHEMBL195268 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191295 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL195315 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL192069 | CENTANAMYCIN | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL183826 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL195268 | — | IC50 | = | 5600.0 | nM | 5.25 |