Assay Detail
Functional
CHEMBL837473
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against LPS-induced release of IL-1 beta in human whole blood
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Cell Type | Cell line |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.17 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197096 | — | — | 1 | 6.38 |
| CHEMBL265032 | — | — | 1 | 6.34 |
| CHEMBL436291 | — | — | 1 | 6.34 |
| CHEMBL193563 | — | — | 1 | 6.26 |
| CHEMBL365359 | — | — | 1 | 6.21 |
| CHEMBL372301 | — | — | 1 | 6.01 |
| CHEMBL197267 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197096 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL265032 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL436291 | — | IC50 | = | 454.0 | nM | 6.34 |
| CHEMBL193563 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL365359 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL372301 | — | IC50 | = | 974.0 | nM | 6.01 |
| CHEMBL197267 | — | IC50 | = | 2420.0 | nM | 5.62 |