Assay Detail
Functional
CHEMBL837474
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Inhibitory concentration against LPS-induced release of TNF-alpha in human whole blood
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Cell Type | Cell line |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.07 | 6.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436291 | — | — | 1 | 6.78 |
| CHEMBL197096 | — | — | 1 | 6.62 |
| CHEMBL193563 | — | — | 1 | 6.26 |
| CHEMBL372301 | — | — | 1 | 6.02 |
| CHEMBL365359 | — | — | 1 | 5.81 |
| CHEMBL197267 | — | — | 1 | 5.74 |
| CHEMBL265032 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436291 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL197096 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL193563 | — | IC50 | = | 547.0 | nM | 6.26 |
| CHEMBL372301 | — | IC50 | = | 948.0 | nM | 6.02 |
| CHEMBL365359 | — | IC50 | = | 1563.0 | nM | 5.81 |
| CHEMBL197267 | — | IC50 | = | 1827.0 | nM | 5.74 |
| CHEMBL265032 | — | IC50 | = | 5850.0 | nM | 5.23 |