Assay Detail
Functional
CHEMBL837482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit cell proliferation by 50% in KBH5.0 tumor cell line; overexpress BCRP
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.09 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186397 | — | — | 1 | 8.40 |
| CHEMBL184515 | — | — | 1 | 7.52 |
| CHEMBL184236 | — | — | 1 | 7.16 |
| CHEMBL187426 | — | — | 1 | 6.96 |
| CHEMBL187041 | — | — | 1 | 6.30 |
| CHEMBL186690 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186397 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL184515 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL184236 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL187426 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL187041 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL186690 | — | IC50 | = | 600.0 | nM | 6.22 |