Assay Detail
Functional
CHEMBL837525
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Concentration required for 50% inhibition of Col2 cell line (human colon carcinoma cells)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Col2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 5'-substituted fluoro-neplanocin A analogues: importance of a hydrogen bonding donor at 5'-position for the inhibitory activity of S-adenosylhomocysteine hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.90 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64718 | FLUORO-NEPLANOCIN A | — | 1 | 5.85 |
| CHEMBL183737 | — | — | 1 | 4.45 |
| CHEMBL187650 | — | — | 1 | 4.41 |
| CHEMBL363897 | — | — | 1 | - |
| CHEMBL365452 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64718 | FLUORO-NEPLANOCIN A | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL183737 | — | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL187650 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL363897 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL365452 | — | IC50 | > | 100000.0 | nM | - |