Assay Detail
Functional
CHEMBL837595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the cytotoxicity against KB-V1 cell line expressing P-glycoprotein
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.34 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360439 | — | — | 1 | 7.21 |
| CHEMBL363453 | — | — | 1 | 6.93 |
| CHEMBL181650 | — | — | 1 | 6.84 |
| CHEMBL182270 | — | — | 1 | 5.75 |
| CHEMBL360165 | — | — | 1 | 5.68 |
| CHEMBL182109 | — | — | 1 | 5.64 |
| CHEMBL183335 | — | — | 1 | - |
| CHEMBL362056 | — | — | 1 | - |
| CHEMBL367578 | — | — | 1 | - |
| CHEMBL182526 | — | — | 1 | - |
| CHEMBL184777 | — | — | 1 | - |
| CHEMBL367814 | — | — | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360439 | — | IC50 | = | 62.4 | nM | 7.21 |
| CHEMBL363453 | — | IC50 | = | 117.3 | nM | 6.93 |
| CHEMBL181650 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL182270 | — | IC50 | = | 1794.0 | nM | 5.75 |
| CHEMBL360165 | — | IC50 | = | 2089.0 | nM | 5.68 |
| CHEMBL182109 | — | IC50 | = | 2291.0 | nM | 5.64 |
| CHEMBL183335 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL362056 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL367578 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL182526 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL184777 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL367814 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL428647 | PACLITAXEL | IC50 | > | 3000.0 | nM | - |