Assay Detail
Functional
CHEMBL837773
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In-vitro inhibitory concentration for human tumor BEL-7402 cell-line was determined using MTT assay after 3 days of incubation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Bel-7402 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antitumor activity of the hexacyclic camptothecin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.19 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189205 | — | — | 1 | 8.80 |
| CHEMBL193123 | — | — | 1 | 8.59 |
| CHEMBL192692 | — | — | 1 | 8.59 |
| CHEMBL193278 | — | — | 1 | 8.36 |
| CHEMBL366213 | — | — | 1 | 8.13 |
| CHEMBL190617 | — | — | 1 | 8.12 |
| CHEMBL189108 | — | — | 1 | 8.11 |
| CHEMBL363863 | — | — | 1 | 7.96 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 7.89 |
| CHEMBL280320 | — | — | 1 | 7.82 |
| CHEMBL364308 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189205 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL193123 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL192692 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL193278 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL366213 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL190617 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL189108 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL363863 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL280320 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL364308 | — | IC50 | = | 19.0 | nM | 7.72 |